Origin: Italy, United States

Probiotics, also known as the “good bacteria” of the body, are microscopic living organisms intended to benefit our health by improving or restoring the gut flora.

While the use of probiotics for purported health benefits is far from new - dating back to Roman times! – their use is increasingly being studied for potential benefits such as preventing infections, boosting the immune system, maintaining healthy skin, and strengthening our nervous system. Much of the discussion emerging from the growing amount of probiotic research centers on the ability of probiotics to support gastrointestinal (GI) health. Ongoing research is also suggesting that a strong biochemical connection exists between gut and brain -- operating through the gut-brain axis -- thus the benefits of probiotics could extend to mental health in addition to physical health.

But not all probiotics are the same and different strains can impact the body differently. The american gastroenterological association states that not everybody benefits from the same probiotics. Based on our knowledge of ongoing probiotic research, along with our understanding of human metabolism, we chose to include a diverse combination of four specific and thoroughly-researched probiotic strains to provide a variety of benefits on digestive and overall health.

Lactobacillus rhamnosus GG Bifidobacterium lactis HN019 Bifidobacterium longum BI-05 Bacillus Subtilis

Lactobacillus rhamnosus GG is one of the most vigorously studied probiotic strains, with over 800 studies conducted to date. Its ability to resist stomach acid and intestinal bile degradation allows it to survive in the body longer than most other probiotics, thereby increasing its potential of offering health advantages to the host. Several studies suggested that it may help improve the intestinal wall barrier, which could reinforce the immune system. Its immune-modifying properties inspired a number of studies to explore its benefits for GI illnesses, including studies that revealed it can decrease the frequency of antibiotic induced diarrhea and that it can benefit subjects with Irritable Bowel Syndrome (IBS) symptoms.

Bifidobacterium probiotic species play a key role in gut activity and in the immune system. In fact, they are among the first microbes to colonize our digestive tract as infants. They're routinely added to functional foods as active ingredients because of their potential health benefits for the digestive system. Bifidobacterium lactis HN019 is known for its ability to promote gut motility - it can be helpful for people with bowel movement issues and has been shown to improve functional gastrointestinal symptoms (or constipation) in certain populations. It may also improve immune function, and other bifidobacterium species are being studied for their potential ability to support neurocognition and reduce stress.

FUN FACT: Consumption of red wine can lead to an increase in gut bifidobacteria!

Bifidobacterium longum is well-suited for intestinal survival and is known for its ability to promote microbial diversity. This bacteria has properties making it resistant to acidic conditions, enabling it to adhere to intestinal walls - a necessary property to survive the journey down the gastrointestinal tract and confer health benefits on the body. Some studies have further argued that the ability of the BI-05 strain to adhere to the intestinal wall and reside longer in the digestive system may enable it to favorably regulate immune responses, potentially strengthening the body’s response to hostile (or bad) bacteria. Other studies have also suggested that it may modulate brain activity and potentially reduce the negative impact of social stresses.

FUN FACT: it is our most common gut bacteria in infancy, comprising over 90% of the probiotics in our body!

Bacillus subtilis is known for conferring strong benefits on digestive and general health thanks to a strong ability to survive in extreme environments. We use a genome-sequenced and clinically tested strain of Bacillus Subtilis with supported benefits for both digestive and immune health. Developed by our microbiome-specialized manufacturer, benefits such as controlling microbial populations in the gut and optimizing digestion have been supported by multiple human clinical studies. Studies have also revealed this probiotic strains’ ability to form spores that protect healthy microbes from harsh conditions, thereby enabling them to reach the GI tract where they can safely develop. Other studies have suggested that Bacillus Subtilis’ probiotic strains can improve bowel movements and reduce occasional constipation or diarrhea.

FUN FACT: Bacillus subtilis is also the bacterial species holding the record for surviving the longest in space -- 6 years on a NASA satellite!


  • Promote a healthy GI tract
  • Strengthen the immune system
  • Support overall health

Science First

  1. “Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids.”

    - Gut Microbes, 2019.

  2. “Dose-response effect of bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults.”

    - Scandinavian Journal of Gastroenterology, 2011.

  3. “Bifidobacteria and their role as members of the human gut microbiota.”

    - Frontiers in Microbiology, 2016.

  4. “Lactobacillus acidophilus CL1285, lactobacillus casei LBC80R and lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study.”

    - Beneficial Microbes, 2018.

  5. “The effect of bacillus subtilis DE111 on the daily bowel movement profile for people with occasional gastrointestinal irregularity”

    - Journal of Probiotics & Health, 2017.

  6. “Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition.”

    - Neurobiology of Stress, 2019.

  7. “Bifidobacterium longum 1714™ strain modulates brain activity of healthy volunteers during social stress.”

    - American Journal of Gastroenterology, 2019.

  8. “Psychobiotics: Changing the mind with gut bacteria.”

    - American Journal of Gastroenterology, 2019.

  9. “Health promoting activities of probiotics.”

    - Journal of Food Biochemistry, 2019.

  10. For more information, check out the American Gastroenterological Association's website.

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